Wenshe Liu
Adjunct Professor of Pharmaceutical Sciences
Contact
Texas A&M Irma Lerma Rangel College of Pharmacy
1010 W. Ave. B
Kingsville,
TX
78363
wsliu2007@tamu.edu
Education and Training
- Scripps Research Institute, Postdoc in chemical biology, 2005-2007
- University of California-Davis, Ph.D. in chemistry, 2000-2005
- Peking University, B.S. in chemistry, 1996-2000
Research Interests
- Chromatin biology
- Chemical proteomics
- Small molecule drug discovery
- Peptide/phage display drug discovery
- Antibody/nanobody drug discovery
Awards, Recognition and Service
- Texas A&M EDGES Fellow
- Texas A&M Presidential Impact Fellow
- Elected President of Chinese American Chemistry and Chemical Biology Professors’ Association (2023)
- Biomatrik Distinguished Professor Award (2016)
- NSF CAREER Award (2012)
Representative Publications
Chen P.-H.C., Guo X.S., Zhang H.Z., Dubey G.K., Geng Z.Z., Fierke C.A., Xu S., Hampton J.T.*, and Liu W.R.*, “Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors”, ACS Cent. Sci. 2024, 10(4): 782-792.
Geng Z.Z., Atla S., Shaabani N., Vulupala V.R., Yang K.S., Alugubelli Y.R., Khatua K., Chen P.-H.C., Xiao J., Blankenship L.R., Ma X.R., Vatansever E.C., Cho C.-C.D., Ma Y., Allen R., Ji H., Xu S., and Liu W.R.*, A Systematic Survey of Reversible Covalent Dipepitdyl Inhibitors of the SARS-CoV-2 Main Protease, Med. Chem. 2023, 66(16): 11040-11055.
Hampton J.T., Cho C.-C.D., Coleman D.D., Geng Z.Z., Chen P.-H.C., Dubey G.K., Sylvian L.D., Xu S., and Liu W.R.*, “An Amber-Encoding Helper Phage for More Efficient Phage Display of Noncanonical Amino Acids” Nucleic Acids Res. 2023, 51(13): 6566-6577.
Yang K.S., Leeuwon S.Z., Xu S., and Liu W.R.*, “Evolution and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir”, Med. Chem. 2022, 65(13): 8686-8698.
Cao W., Geng Z., Wang N., Pan Q., Guo S., Xu S., Zhou J.*, and Liu W.R.*, “A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells”, Chem. Int. Ed. 2022, 61: e202109550 (Hot Paper; Front Cover).
Cao W., Cho C.-C.D., Geng Z.Z., Shaabani N., Ma X.R., Vatansever E.C., Alugbelli Y.R., Ma Y., Chaki S., Ellenburg W.H., Yang K.S., Qiao Y., Allen R., Neumann B, Ji H.*, Xu S.*, and Liu W.R.*, “Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay”, ACS Cent. Sci. 2022, 8(2):194-204 (Front Cover).
Vatansever E.C., Yang K., Kratch K.C., Drelich A., Cho C.-C., Mellott D.M., Xu S., Tseng C.-T.K.*, and Liu W.R.*, “Bepridil is Potent Against SARS-CoV-2 In Vitro”, Natl. Acad. Sci. U. S. A., 2021, 118(10): e2012201118.
Zhao B., Rowlett C.M., Jing T., Shinde O., Lei Y., West A.P., Liu W.R.*, and Li P.*, “The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS”, Nature, 2020, 587(7835): 673-677.